THE MITOCHONDRIA AND THEIR IMPORTANCE FOR DEEP-DOWN YOUTHFULNESS OF THE SKIN

The mitochondria, which are real energy centers, are small organelles contained within each cell of an organism, and which are responsible for the processes of cellular respiration, and therefore for the stimulation of energy production (ATP, Adenosine Triphosphate) inside the cell, which is necessary in the development of metabolic processes.

Through their activity, the mitochondria also indirectly protect skin lipids, elastin and collagen which are responsible for turgor and elasticity of the skin.

A peculiar feature of the mitochondria is their incessant energy production activity. Precisely for this reason, the mitochondria undergo an early decay, which involves a reduction in energy and a mainly oxidative damage (excessive development of free radicals ROS, Reactive Oxygen Species, in relation to cellular respiration).

This process is particularly problematic in tissues and organs where the mitochondria are more numerous as they must meet a greater demand for energy: muscles, skin, heart, brain and liver. On the skin in particular, this early senescence compromises the lipid matrix and structural proteins, resulting in the “aged” appearance of the skin, of which lines and wrinkles are the most visible sign.^1,2

THE MITOCHONDRIA AND THEIR IMPORTANCE FOR DEEP-DOWN YOUTHFULNESS OF THE SKIN

Through their activity, the mitochondria also indirectly protect skin lipids, elastin and collagen which are responsible for turgor and elasticity of the skin.

Le azioni di Mitochon e i principi attivi più efficaci contro il danno ossidativo

ACTIONS OF MITOCHON AND THE MOST EFFECTIVE ACTIVE INGREDIENTS AGAINST OXIDATIVE DAMAGE

MITOCHON has focused its scientific research on the role of the mitochondria in the processes of skin aging, studying this process and selecting the most effective active ingredients for a profound action on the mechanisms underlying mitochondrial degradation and aging (mitochondrial lipid peroxidation, oxidative stress, protein degeneration).³

MITOCHON COSMETIC
MITOFAST SUPPLEMENT

In particular, the actions of MITOCHON cosmetics are:

PROTECTION OF MITOCHONDRIAL DNA

FOLIC ACID

This substance is involved in supporting all the mechanisms of successful cell replication, (this is where the protective action on mitochondrial DNA manifests itself). It also has an antioxidant activity.

COUNTERACTS MITOCHONDRIAL LIPID PEROXIDATION

GLUTATHIONE

Glutathione allows the transport of thiol groups (sulfur + hydrogen) within the mitochondrion and therefore, through chemical processes, the elimination of radical species by limiting lipid peroxidation. Furthermore, Glutathione has a strong antioxidant action.

SOLAR FILTERS

The chemical and physical sunscreens provide protection from UV rays, which are among the factors that further accelerate the production of free radicals at the mitochondrial and then cellular level, and therefore slow down the degenerative process of mitochondrial peroxidation.

ANTIOXIDANT ACTION

COENZYME Q10, GLUTATHIONE, , FOLIC ACID AND VITAMIN C

These substances, with their powerful antioxidant activity, act by improving the physiological systems of neutralization of free radicals. In particular, vitamin C, in addition to having a high antioxidant power, contributes to the formation of collagen.

PROTEIN DEGENERATION

ANTIOXIDANT FACTORS (COENZYME Q10, GLUTATHIONE AND VITAMIN C),
N-ACETYL-GLUCOSAMINE

Protein degeneration is one of the factors that most results in visible skin aging. Countering this is essential. The presence of antioxidant factors limits this process, but it is not sufficient to act only at the enzymatic level. In fact, the overexpression of enzymes such as Collagenase, which are attributable to the action of UVB, leads to an extensive breakdown of protein, and of collagen specifically.

N-Acetyl Glucosamine, which is the natural precursor of hyaluronic acid and therefore promotes its synthesis, also has an enzymatic inhibiting action, especially of Collagenase.
Vitamin C, in addition to having a well-known antioxidant activity, contributes to the normal formation of collagen.

It is important to take care of the deep-down youthfulness of the skin from the inside too: the MITOFAST supplement, with its buccal formulation (dissolves directly in the mouth) and thanks to its P.AS.S technology, allows you to integrate with, and support, the cosmetic line, for a complete and effective beauty routine.

ANTIOXIDANT ACTION:

RESVERATROL

Resveratrol, a substance naturally produced by various plants, is recognized for the efficacy of its antioxidant and anti-inflammatory characteristics and plays an important role in the regulation processes of the cell cycle and in DNA repair. Generally, however, Resveratrol is poorly absorbed in the gastrointestinal tract. To overcome this, MITOCHON has created the patented P.AS.S. technology which, thanks to absorption via the oral mucosa, avoids this inactivation.

COENZYME Q10

This substance is one of the most important antioxidant molecules produced by our bodies that is capable of antagonizing free radicals.
Unfortunately, many Coenzyme Q10-based supplements are minimally absorbed and therefore have a modest antioxidant effect, while the granular formulation perfected by MITOCHON allows for rapid and high absorption through the oral mucosa.

COUNTERACTING MITOCHONDRIAL PEROXIDATION

N-ACETYL CYSTEINE (NAC)

NAC is very important for replenishing the natural reserves of Glutathione and, like the latter, it is a molecule with strong antioxidant action, which allows the transport of thiol groups within the mitochondrion and therefore, through chemical processes, eliminates the radical species and limits mitochondrial peroxidation.

FORMATION OF HYALURONIC ACID

N-ACETYL GLUCOSAMINE (NAG)

NAG is the natural precursor of hyaluronic acid and stimulates its endogenous production. This formulation choice was considered by MITOCHON to be the most rational in light of the scientific literature that supports its greater absorption compared to hyaluronic acid.

FORMATION OF COLLAGEN

VITAMIN C

Vitamin C has a well-known antioxidant and restructuring potential (collagen synthesis).

PROTECTION OF MITOCHONDRIAL DNA

FOLIC ACID

This substance is involved in supporting all the mechanisms of successful cell replication (this is where the protective action on mitochondrial DNA manifests itself). It also has an antioxidant activity.

P.AS.S TECHNOLOGY
HOW TO BEST CONVEY ACTIVE INGREDIENTS

Among the lesser known factors that determine the effectiveness of a cosmetic is the way in which the active ingredients are conveyed.

In fact, the stratum corneum, due to its barrier function, tends to hinder the permeation of substances carried through the epidermis. The consequence of this phenomenon is a drastic reduction in the beneficial action of the cosmetic.

AN INNOVATIVE MICELLE TECHNOLOGY FOR MORE EFFECTIVE DELIVERY.

MITOCHON research has developed the new, patented, Permeable AntioxidantS System (P.AS.S.) technology which allows, on the one hand, the effective permeation of active substances through the skin and, on the other, their protection against oxidative and degradative phenomena.

A self-emulsifying system such as this, characterized by the oily and aqueous phase, guarantees high elasticity and is able to prevent degradation processes.

The association between a vitamin and a fatty acid, namely Ascorbyl palmitate and oleic acid, creates a micelle structure that allows for transcutaneous penetration, in particular of Coenzyme Q10 and Glutathione.³

Mitochon Permeable PASS Technology Antioxidants System

An innovative micelle technology for more effective delivery.

MITOCHON research has developed the new, patented, Permeable AntioxidantS System (P.AS.S.)^® technology which allows, on the one hand, the effective permeation of active substances through the skin and, on the other, their protection against oxidative and degradative phenomena. A self-emulsifying system such as this, characterized by the oily and aqueous phase, guarantees high elasticity and is able to prevent degradation processes. The association between a vitamin and a fatty acid, namely Ascorbyl palmitate and oleic acid, creates a micelle structure that allows for transcutaneous penetration, in particular of Coenzyme Q10 and Glutathione. ³

The effectiveness of a cosmetic often depends on the mode of delivery of the active ingredients.

In fact, the stratum corneum, due to its barrier function, tends to hinder the permeation of substances carried through the epidermis. The consequence of this phenomenon is a drastic reduction in the beneficial action of the cosmetic.

P.AS.S^® TECHNOLOGY: HOW TO BEST CONVEY ACTIVE INGREDIENTS

AN EFFECTIVENESS PROVEN BY NUMEROUS CLINICAL STUDIES

Subjected to numerous clinical tests, the MITOCHON cosmeceutical line has demonstrated:

MOISTURIZING EFFICACY (at 8 weeks)

+17,3%

Clinical efficacy study carried out on 20 volunteers between 35 and 65 years of age. The results show the difference in the mean of the values after 8 weeks of treatment with concentrated serum, day cream and night cream.
Moisturizing efficacy evaluated by MoistureMeterSC, Delfin; statistically significant results (p-value = 0.042).
Elasticizing efficacy evaluated by ElastiMeter, Delfin; statistically significant results (p-value = 0.008).
Anti-wrinkle efficacy (Ra / Skin texture and Rspan / Deep expression lines) evaluated by Antera 3D^® with CS software, Miravex; statistically significant results (p-value = 0.047 and 0.041).

ELASTICIZING EFFICACY (at 8 weeks)

+20,3%

ANTI-WRINKLE EFFICACY Ra (superficial lines) (at 8 weeks)

-9,9%

ANTI-WRINKLE EFFICACY Rspan (deep lines) (at 8 weeks)

-11,7%

Below are the 3D digital photos of two women who participated in the clinical study on 20 subjects. Compared to the average, these are the most effective anti-wrinkle results achieved after 8 weeks of treatment with the MITOCHON line.

Significant reduction in wrinkles after 8 weeks of treatment with the MITOCHON cosmeceutical line

Subject 5:
-43% superficial lines; -50% deep lines

Subject 13:
-40% superficial lines; -38% deep lines

Examples of high-resolution and digital 3D images obtained with Antera 3D^® at Time 0 and at the 8-week check for the measurement of skin texture (Ra) and deep expression lines (Rspan). Clinical study carried out on 20 volunteers aged between 35 and 65 years.

ANTIOXIDANT EFFICACY

-71%

p-value<0.01 Anova

Significant reduction in ROS (Reactive Oxygen Species)

MITOCHON Multifunctional Concentrated Anti-Wrinkle Serum Skin Protection Factor (SPF) 6 has demonstrated antioxidant activity by significantly preventing pro-oxidant activity due to UVA radiation

The antioxidant test, carried out on the serum, can be considered representative of the antioxidant efficacy of the entire MITOCHON line, since all three formulations are characterized by high concentrations of antioxidant active ingredients.
The results are excellent since the positive control used in the study is pure Vitamin E, which does not exist in such concentrations in any cosmetic on the market.

MOISTURIZING EFFICACY (at 8 weeks)

+17,3%

ELASTICIZING EFFICACY (at 8 weeks)

+20,3%

ANTI-WRINKLE EFFICACY Ra (superficial lines) (at 8 weeks)

-9,9%

ANTI-WRINKLE EFFICACY Rspan (deep lines) (at 8 weeks)

-11,7%

Significant reduction in wrinkles after 8 weeks of treatment with the MITOCHON cosmeceutical line

Subject 5:
-43% superficial lines; -50% deep lines

Mitochon riduzione significatica della rugosità dopo 8 settimane di trattamento

Subject 13:
-40% superficial lines; -38% deep lines

ANTIOXIDANT EFFICACY

-71%

p-value<0.01 Anova

Significant reduction in ROS (Reactive Oxygen Species)

MITOCHON Multifunctional Concentrated Anti-Wrinkle Serum Skin Protection Factor (SPF) 6 has demonstrated antioxidant activity by significantly preventing pro-oxidant activity due to UVA radiation

Mitochon Mitoclean AG detergente spray viso mani

BIBLIOGRAPHY

Mitochondrial bioenergetics in aging G. Lenaz, M. D’Aurelio, M. Merlo Pich, M.L. Genova, B. Ventura, C. Bovina, G. Formiggini, G. Parenti Castelli; Biochimica et Biophysica Acta 1459 (2000) 397-404
Mitochondria as a therapeutic target for common pathologies Michael P. Murphy and Richard C. Hartley Nature Reviews – Drug Discovery Vol: 17 (2018); 865
Role of Mitochondria in Photoaging of Human Skin: The Defective Powerhouse Model.
Jean Krutmann and Peter Schroeder, Journal of Investigative Dermatology Symposium Proceeding (2009) Volume 14, 44-49

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THE MITOCHONDRIA AND THEIR IMPORTANCE FOR DEEP-DOWN YOUTHFULNESS OF THE SKIN

THE MITOCHONDRIA AND THEIR IMPORTANCE FOR DEEP-DOWN YOUTHFULNESS OF THE SKIN

ACTIONS OF MITOCHON AND THE MOST EFFECTIVE ACTIVE INGREDIENTS AGAINST OXIDATIVE DAMAGE

PROTECTION OF MITOCHONDRIAL DNA

COUNTERACTS MITOCHONDRIAL LIPID PEROXIDATION

ANTIOXIDANT ACTION

PROTEIN DEGENERATION

ANTIOXIDANT ACTION:

COUNTERACTING MITOCHONDRIAL PEROXIDATION

FORMATION OF HYALURONIC ACID

FORMATION OF COLLAGEN

PROTECTION OF MITOCHONDRIAL DNA

P.AS.S TECHNOLOGY HOW TO BEST CONVEY ACTIVE INGREDIENTS

AN INNOVATIVE MICELLE TECHNOLOGY FOR MORE EFFECTIVE DELIVERY.

AN EFFECTIVENESS PROVEN BY NUMEROUS CLINICAL STUDIES

P.AS.S TECHNOLOGY
HOW TO BEST CONVEY ACTIVE INGREDIENTS